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Cytologic and histologic findings in women using an IUD
Obstetrics and Gynecology
|November 1, 1981
Summary
Intrauterine contraceptive device (IUD) use is linked to atypical squamous cells in cervical smears. The study found these cells originate from the endometrium and often resolve after IUD removal, recommending conservative follow-up.
Area of Science:
- Gynecology
- Cytopathology
- Reproductive Health
Background:
- Atypical squamous metaplastic cells in cervical smears are common in intrauterine contraceptive device (IUD) users.
- The origin of these atypical cells has been unclear.
Purpose of the Study:
- To identify the source of atypical squamous metaplastic cells observed in cervical smears of IUD users.
- To correlate these cytologic findings with histologic data.
Main Methods:
- Cytologic data analyzed from 61,151 women, including 1,401 IUD users.
- Histologic data collected from endometrial curettings and IUD scrapes in 102 women.
Main Results:
- The endometrial surface epithelium is identified as the primary source of atypical cells in cervical smears from IUD users.
- Epithelial atypia frequently resolved after IUD removal.
Conclusions:
- The study implicates the endometrium as the source of atypical cells in IUD users.
- Conservative follow-up is recommended for women with cytologic metaplastic atypia during IUD use.