[Effect of the intermittent and continuous action of dimethylformamide on adaptation processes]

Two series of experiments were carried out with 960 mg/kg and 3840 mg/kg DMF, applied dermally to albino rats every second, third day and daily as well. The treatment scheme quarantees equitoxic quantities of DMF with a dynamic observation by the 4th, 8th, 14th and 28th day from the beginning of the exposure and after 14 days of rehabilitation. The complex investigation with integral and specific clinical-laboratory tests revealed a cumulation of the toxic effect with progressing changes in the liver function, better manifested with the intermittent regimes. The dose of 3840 mg/kg induced distinct deviations in the lipid metabolism and serum enzymes. In contact with 960 mg/kg DMF, a phase-state was established during the first terms of observation with the development of adaptation under a monotonous effect and absence of restoration -- mainly in case of intermittent effect. Dermal toxicity of DMF should be given consideration in the assessment of the risk from exposure during production of polyacryl fibres.