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Related Experiment Videos

[Basis for a specific-active immunotherapy in malignant melanoma]

P A Mutzner, G M Stuhlmiller, H F Seigler

    Schweizerische Medizinische Wochenschrift
    |September 5, 1981
    PubMed
    Summary

    Malignant melanoma cells possess specific antigens, confirmed by immunofluorescence and immunoautoradiography. This discovery supports active immunotherapy development for melanoma patients using melanoma cells and BCG.

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    Area of Science:

    • Immunology
    • Oncology

    Context:

    • Malignant melanoma is recognized as antigenic since 1968.
    • Duke University Medical Center is developing specific active immunotherapy for melanoma.

    Purpose:

    • To identify and characterize melanoma-specific antigens on tumor cell surfaces.
    • To establish a basis for active immunotherapy in melanoma patients.

    Summary:

    • Hyperimmunization of a chimpanzee with cultured melanoma cells generated xeno-antiserum.
    • After absorption, indirect immunofluorescence and immunoautoradiography confirmed melanoma-specific tumor-associated antigens on cell surfaces.
    • These antigens appear to be cross-reactive among melanoma cells.

    Impact:

    • The identification of melanoma-specific antigens provides a target for immunotherapy.

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  • This research supports the ongoing clinical trials at Duke University Medical Center involving melanoma patients treated with melanoma cells and BCG.