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Related Experiment Videos

Post-ischemic hypermetabolism in cat brain

E M Nemoto, K A Hossmann, H K Cooper

    Stroke
    |September 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Alpha and beta receptor blockade impacts brain blood flow and metabolism after global ischemia. Beta blockade initially reduced cerebral blood flow, while alpha blockade partially restored it, affecting brain oxygen consumption.

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    Area of Science:

    • Neuroscience
    • Cerebrovascular Physiology
    • Pharmacology

    Background:

    • Delayed postischemic hypoperfusion and hypermetabolism can impair neurologic recovery after transient global brain ischemia.
    • Catecholamines acting via adrenergic receptors are implicated in these detrimental post-ischemic effects.

    Purpose of the Study:

    • To evaluate the effects of alpha and beta adrenergic receptor blockade on cerebral blood flow (CBF) and metabolism following transient global brain ischemia.
    • To elucidate the role of adrenergic receptors in modulating cerebrovascular tone and brain metabolism in the acute post-ischemic period.

    Main Methods:

    • Transient global brain ischemia was induced in anesthetized cats via arterial hypotension and neck tourniquet.
    • Cerebral blood flow was measured using 133Xe clearance, and arterial/venous blood gases, glucose, and lactate were analyzed.

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  • Cerebral cortex glucose and lactate levels were measured post-ischemia; some cats received propranolol (beta-blocker) or a combination of propranolol and phentolamine (alpha-blocker).

    • Main Results:

    • In untreated cats, post-ischemic changes included a reversal of fast and slow-flow compartments and a 2-3 fold increase in brain oxygen consumption.
    • Propranolol attenuated fast-flow compartment size and compromised CBF and glucose/lactate oxidation.
    • Phentolamine partially restored fast-flow compartment size and improved perfusion and oxygen consumption in propranolol-treated cats.

    Conclusions:

    • Beta-adrenergic receptors play a predominant role in modulating cerebrovascular tone within the first 30 minutes post-ischemia.
    • Adrenergic modulation of cerebrovascular tone is diminished by 1 hour post-ischemia.
    • Beta blockade can impair brain oxygen consumption by reducing oxygen supply, an effect partially reversed by alpha blockade with phentolamine.