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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Neurological infections caused by herpes simplex virus in adults

A Ferencz, L Binder, F Kovács

    Infection
    |January 1, 1978
    PubMed

    Insights

    Herpes simplex virus caused 26 of 281 neuro-infections over 33 months. This virus led to various neurological conditions, including severe encephalitis, highlighting diagnostic and therapeutic challenges.

    Area of Science:

    • Neurology
    • Virology
    • Infectious Diseases

    Background:

    • Neuroinfections pose significant diagnostic and therapeutic challenges.
    • Herpes simplex virus (HSV) is a known cause of central nervous system infections.

    Purpose of the Study:

    • To determine the prevalence and clinical spectrum of herpes simplex virus (HSV) in neuroinfection cases.
    • To discuss the diagnostic and therapeutic considerations for HSV neuroinfections.

    Main Methods:

    • Prospective study over 33 months.
    • Testing 281 neuroinfection cases for HSV.
    • Virus isolation from cerebrospinal fluid (CSF) and serological tests were employed for HSV identification.

    Main Results:

    • Herpes simplex virus (HSV) was identified as the etiological agent in 26 out of 281 (9.25%) neuroinfection cases.
    • Clinical presentations included severe encephalitis (4 cases), less severe encephalitis/meningoencephalitis (12 cases), aseptic meningitis (7 cases), and other neurological syndromes.

    Conclusions:

    • Herpes simplex virus (HSV) is a significant cause of neuroinfections with diverse clinical manifestations.
    • Effective diagnosis and timely treatment are crucial for managing HSV neuroinfections and improving patient outcomes.

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