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Related Experiment Videos

Reactions in the cytotoxic leucocyte test

J Ruokonen

    Allergologia Et Immunopathologia
    |July 1, 1981
    PubMed
    Summary

    The cytotoxic leucocyte test (CLT) is a sensitive screening tool for food allergies, identifying common allergens like malt and milk. Results vary by age, with cow milk affecting children and malt affecting adults.

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    Area of Science:

    • Immunology
    • Allergology
    • Clinical Diagnostics

    Background:

    • The cytotoxic leucocyte test (CLT) is a diagnostic method used to identify adverse reactions to specific food allergens.
    • Previous literature suggests certain foods are more frequently implicated in allergic reactions.

    Purpose of the Study:

    • To analyze the results of a large cohort of cytotoxic leucocyte tests (CLTs) to identify common food allergens and assess the test's sensitivity.
    • To investigate the influence of patient age on CLT results for specific food allergens.

    Main Methods:

    • Analysis of 1824 cytotoxic leucocyte tests (CLTs) involving 23 different food allergens.
    • Statistical review of reaction frequencies and comparison across different food types and age groups.

    Main Results:

    • Malt, orange, rye, milk, corn, tomato, oats, wheat, brewers yeast, and rice were the most frequent reactive foods in CLTs.
    • CLT results showed age-dependent patterns, with cow milk reactions more common in children and malt reactions in adults.
    • The CLT demonstrated high sensitivity, with at least one reaction observed in 92.1% of the tests.

    Conclusions:

    • The cytotoxic leucocyte test (CLT) is a sensitive method for screening foods suspected of causing allergy symptoms.
    • CLT can aid in preliminary identification of potential food allergens before proceeding to elimination and provocation trials.
    • Age is a significant factor influencing CLT outcomes for specific food allergens, such as cow milk and malt.

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