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Related Experiment Videos

Amines in the subretinal fluid and aqueous

G Kranias, J G Dobbie

    American Journal of Ophthalmology
    |November 1, 1981
    PubMed
    Summary

    Researchers identified seven amines, including histamine, in retinal detachment fluid. Histamine presence in fresh detachments suggests early inflammation, aligning with clinical observations of uveitis.

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    Area of Science:

    • Ophthalmology
    • Biochemistry

    Background:

    • Retinal detachment is a serious ocular condition.
    • The biochemical composition of subretinal fluid is not fully understood.
    • Inflammatory processes are often associated with retinal detachment.

    Purpose of the Study:

    • To identify and quantify amines in subretinal fluid and aqueous humor from patients with retinal detachment.
    • To investigate the potential role of these amines in the pathophysiology of retinal detachment.

    Main Methods:

    • Analysis of 49 subretinal fluid samples and 9 aqueous humor samples.
    • Utilized techniques to identify and quantitate seven specific amines: histamine, dopamine, methylamine, ethanolamine, dimethylamine, pyridoxamine, and piperidine.

    Main Results:

    • Seven amines were successfully identified and quantified in both subretinal fluid and aqueous humor.
    • The amine profiles in subretinal fluid were comparable to those found in aqueous humor.
    • Histamine was detected exclusively in subretinal fluid from fresh retinal detachments.

    Conclusions:

    • The presence of histamine in fresh retinal detachment fluid suggests an early inflammatory component.
    • Findings support the clinical observation linking mild uveitis with rhegmatogenous retinal detachment.
    • Amine composition may offer insights into the early stages of retinal detachment.

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