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Related Concept Videos

Hemoglobin01:24

Hemoglobin

7.1K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
7.1K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.0K
Multiple Allele Traits01:49

Multiple Allele Traits

37.7K
The Concept of Multiple Allelism
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

13.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
13.9K
Blood Types02:20

Blood Types

22.0K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
22.0K
The ABO Blood Group01:12

The ABO Blood Group

4.2K
The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
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Related Experiment Videos

[Recent data concerning abnormal hemoglobins (author's transl)]

D Labie, J Elion

    Annales De Biologie Clinique
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This study focuses on abnormal hemoglobins, classifying them by frequency, ethnic risk, and clinical impact like hemolytic anemia. Advanced techniques aid diagnosis, preventing unnecessary patient testing.

    Related Experiment Videos

    Area of Science:

    • Hematology
    • Clinical Chemistry

    Context:

    • Abnormal hemoglobins present diverse clinical challenges.
    • Understanding hemoglobin variants is crucial for patient management.

    Purpose:

    • To categorize abnormal hemoglobins based on clinical relevance.
    • To highlight diagnostic approaches and their rationale.
    • To emphasize the importance of accurate diagnosis in patient care.

    Summary:

    • The study classifies abnormal hemoglobins by frequency, ethnic origin, and clinical manifestations (e.g., hemolytic anemia, cyanosis).
    • It discusses the evolution of diagnostic methods, including high-resolution techniques like isoelectric focusing.
    • Examples illustrate the classification and diagnostic considerations, avoiding an exhaustive list.

    Impact:

    • Accurate diagnosis of abnormal hemoglobins can prevent prolonged and potentially hazardous medical investigations.
    • Improved understanding aids in managing patients with hemoglobinopathies.
    • Highlights the clinical utility of advanced diagnostic techniques in hematology.