[Effect of fructose derivatives on platelet aggregation]

Fructose diphosphate, fructose monophosphate and inorganic phosphate decrease platelet aggregation. Fructose does not affect the function under study. The most pronounced antiaggregation action is displayed by fructose diphosphate which enhances calcium binding with thrombocytic membranes. The action of fructose diphosphate depends on the time of its presence in the blood channel. Fifteen minutes after injection the substance inhibits the formation of experimental thrombocytic thromboses. After one hour such an effect does not manifest since fructose diphosphate is absent from the blood flow by that time.