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Bromocriptine reduction of prolactinoma size
Fertility and Sterility
|December 1, 1981
Summary
Bromocriptine effectively treats large prolactinomas by reducing tumor size and alleviating symptoms. This study suggests bromocriptine is a common and effective initial therapy for patients with large prolactinomas.
Area of Science:
- Endocrinology
- Neurosurgery
- Oncology
Background:
- Large prolactinomas can cause significant symptoms due to hyperprolactinemia and mass effect.
- Treatment options for large prolactinomas include surgery, radiation, and medication.
Purpose of the Study:
- To evaluate the efficacy of bromocriptine in reducing the size of large prolactinomas.
- To assess the impact of bromocriptine on symptoms associated with hyperprolactinemia and tumor mass.
Main Methods:
- Prospective study of eight consecutive patients with large prolactinomas.
- Treatment with bromocriptine.
- Assessment of tumor size and prolactin levels via computerized tomographic (CT) scanning and serum assays.
- Evaluation of symptom resolution.
Main Results:
- All eight patients experienced symptom disappearance within 3 months.
- All eight patients showed a significant decrease in prolactinoma size on CT scans.
- Bromocriptine treatment was well-tolerated.
Conclusions:
- Bromocriptine is an effective initial therapy for large prolactinomas.
- Significant tumor size reduction and symptom improvement are commonly observed with bromocriptine treatment.
- Further research should explore long-term outcomes and compare bromocriptine with other treatment modalities.