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The lipocytes in normal human liver. A quantitative study

M P Giampieri, A M Jezequel, F Orlandi

    Digestion
    |January 1, 1981
    PubMed
    Summary
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    Quantitative analysis reveals lipocyte (fat-storing cells, Ito cells) volume density and number are higher in centrolobular liver areas. This study highlights the necessity of quantitative data for assessing lipocyte variations.

    Area of Science:

    • Hepatology
    • Cell Biology
    • Liver Histology

    Background:

    • Lipocytes, also known as Ito cells, are specialized fat-storing cells residing in the liver.
    • Accurate quantification of lipocytes is crucial for understanding liver physiology and pathology.

    Purpose of the Study:

    • To quantitatively analyze the volume density and number of lipocytes in healthy human liver tissue.
    • To investigate the zonal distribution of lipocytes within the liver lobule.
    • To explore potential correlations between lipocyte parameters and parenchymal steatosis.

    Main Methods:

    • Quantitative analysis of lipocytes was performed on needle liver biopsies from 8 subjects without hepatic impairment.
    • Measurements included mean volume density of lipocytes and the Ito cell index (number of lipocytes per 1,000 hepatocytes).

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  • Zonal distribution analysis compared centrolobular and periportal areas.

    • Main Results:

    • The mean volume density of lipocytes was 1.88 ± 0.25% of parenchymal volume.
    • The Ito cell index was 63.45 ± 19.18.
    • Lipocyte values were significantly higher in centrolobular compared to periportal zones.
    • No correlation was found between lipocyte volume density/number and parenchymal steatosis volume density.

    Conclusions:

    • Quantitative data are essential for evaluating variations in lipocyte volume and number due to high coefficients of variation.
    • Lipocyte distribution is not uniform, with higher concentrations in centrolobular regions of healthy livers.
    • Further research is needed to elucidate the functional significance of these quantitative findings.