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[Intermittent claudication: topical treatment with isosorbide dinitrate ointment. Preliminary results]
Giornale Italiano Di Cardiologia
|January 1, 1981
Summary
Topical isosorbide dinitrate ointment significantly improved walking capacity in patients with peripheral vascular disease. Long-term local application demonstrated effectiveness, suggesting a localized therapeutic effect for claudication intermittens.
Area of Science:
- Vascular Medicine
- Pharmacology
Context:
- Peripheral vascular disease (PVD) and claudication intermittens present significant mobility challenges.
- Current treatments for PVD have limitations, prompting investigation into novel therapeutic approaches.
Purpose:
- To evaluate the efficacy of topical isosorbide dinitrate ointment in treating severe claudication intermittens associated with PVD.
- To assess both subjective patient reports and objective treadmill stress test outcomes.
Summary:
- A study involving 10 patients with severe claudication intermittens assessed the effects of topical isosorbide dinitrate ointment.
- Patients applied 100 mg of the ointment three times daily for 30-45 days.
- Significant improvements in walking distance (pain-free and maximal) were observed after 15-20 days of treatment, with high statistical significance (p<0.05 and p<0.01).
- No acute effect was noted; improvement appeared cumulative with long-term use.
Impact:
- Preliminary findings suggest long-term local application of isosorbide dinitrate is an effective treatment for peripheral vascular disease.
- The study indicates a potential localized pharmacological action of isosorbide dinitrate in PVD management.
- This research opens avenues for exploring topical vasodilators in managing ischemic limb conditions.