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Globular hepatic amyloid--an unusual morphologic presentation

G C Kanel, T Uchida, R L Peters

    Hepatology (Baltimore, Md.)
    |November 1, 1981
    PubMed
    Summary
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    This study identifies a rare form of hepatic amyloidosis presenting as eosinophilic globules within the liver. These globules share features with classic amyloid but represent a distinct presentation, not an early stage.

    Area of Science:

    • Pathology
    • Gastroenterology
    • Histology

    Background:

    • Hepatic amyloid typically infiltrates sinusoids, portal tracts, and arterioles.
    • Classic hepatic amyloidosis lacks distinct clinical or laboratory markers.

    Purpose of the Study:

    • To characterize a rare presentation of hepatic amyloidosis involving eosinophilic globules.
    • To differentiate this presentation from classic hepatic amyloid deposition.

    Main Methods:

    • Histochemical analysis of eosinophilic globules.
    • Electron microscopy of hepatic tissue.
    • Clinical and laboratory data review of 14 cases.

    Main Results:

    • Identified round to oval eosinophilic globules (5-40 micrometers) in the space of Disse and portal tracts.

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  • Globules exhibited histochemical and ultrastructural characteristics of amyloid.
  • No unique clinical or laboratory features distinguished this form from classic hepatic amyloidosis.
  • Absence of multiple myeloma and limited monoclonal gammopathy observed.

    • Conclusions:

    • This globular hepatic amyloidosis is an original, rare presentation, not an early stage of systemic amyloidosis.
    • Further investigation is needed to understand the pathogenesis and clinical implications of this distinct amyloid deposition pattern.