[Importance of microcirculation in the pathogenesis of various disease conditions, especially hyperplasia and...

The possibility is considered that a contraction or an increase in the tone of the smooth muscular fibrocells of the vessels may direct the blood flow prevalently thorough preferential channels, with elusion of much of the capillary circulation. This event may lead to a slowdown or change in the function of organs and systems. The persistence of preferential route circulation leads to respiratory and metabolic trouble in the cells of tissues and basic and fibrillar substance of connectives. The main consequences of such a condition are thought to be a reduction in cationic pump activity, a reduction in synthesis of highly energetic products and a numerical increase in the synthesis of structurally simpler proteins. The possibility that a microcirculatory disturbance, triggering tissue hypoxia and permitting the presence of substrates, may be considered as the promoter of neoplastic proliferation, is suggested. Finally, the principles by which von Ardenne instituted prophylaxis of neoplasia and the diffusion of metastasis are enhanced.