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[Testing a cellulose diacetate membrane for plasma exchange (author's transl)]
La Nouvelle Presse Medicale
|November 21, 1981
Summary
This study shows cellulose diacetate membranes effectively reduce immunoglobulin and complement levels during plasma exchange (PE). The membrane proved reusable and suitable for intensive care units.
Area of Science:
- Biomaterials Science
- Immunology
- Nephrology
Context:
- Plasma exchange (PE) is a therapeutic apheresis technique used to remove harmful substances from the blood.
- Cellulose diacetate membranes are employed in various medical devices, including those for blood filtration.
Purpose:
- To evaluate the efficacy and reusability of a cellulose diacetate membrane for plasma exchange.
- To assess the reduction of immunoglobulins (IgG, IgA, IgM) and complement factors (C3, C4, Factor B) during PE.
Summary:
- Sixty plasma exchanges (PE) were performed on 16 patients using a cellulose diacetate membrane.
- Two plasma volumes (72.3 ± 16 ml/kg) significantly reduced IgG, IgA, and IgM to approximately 30% of pre-exchange levels.
- Complement fractions C3, C4, and Factor B were reduced to around 32-36% of pre-exchange values.
- The membrane demonstrated consistent performance after up to 3 consecutive uses in 7 patients.
Impact:
- The cellulose diacetate membrane is effective in reducing key immunological markers during PE.
- Its reusability and ease of application make it a practical option for intensive care units.
- This finding supports the use of cellulose diacetate membranes in apheresis procedures for various clinical indications.