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The T/t-complex in the mouse: mutations that impair differentiation

D Bennett

    Progress in Clinical and Biological Research
    |January 1, 1981
    PubMed
    Summary
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    Mouse T/t-complex mutations impact embryonic development and sperm formation, linked to cell surface abnormalities. Researchers identified distinct molecular changes, including a specific protein and oligosaccharides, associated with these mutations.

    Area of Science:

    • Developmental biology
    • Genetics
    • Immunology

    Background:

    • The mouse T/t-complex harbors genetic factors influencing embryonic development and spermatogenesis.
    • t-mutations are implicated in cell surface abnormalities, suggested by morphological, serological, and biochemical studies.

    Purpose of the Study:

    • To identify the molecular basis of cell surface abnormalities associated with lethal t-haplotypes.
    • To investigate the nature of molecules affected by T/t-complex mutations.

    Main Methods:

    • Biochemical analysis to characterize molecular changes.
    • Serological studies to define antigenic determinants.
    • Examination of over 30 independent t-haplotypes.

    Main Results:

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    • Identified a 63,000-dalton non-glycosylated protein as a direct gene product in mutant t-haplotypes affecting tail development.
    • Demonstrated that serologically defined antigenic determinants of lethal t-haplotypes reside on different oligosaccharides.
    • Found at least two distinct types of molecules associated with complex lethal t-haplotypes.

    Conclusions:

    • T/t-complex mutations affect distinct molecular entities, including proteins and carbohydrates, at the cell surface.
    • These findings provide insights into the arrangement and function of mutant factors within the T/t-complex.
    • The study highlights the molecular heterogeneity underlying T/t-complex associated developmental defects.