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Intrasubject variability of pulmonary function testing in healthy children

A A Hutchison, A Erben, L A McLennan

    Thorax
    |May 1, 1981
    PubMed
    Summary

    Repeat pulmonary function testing in children shows vital capacity is the most reproducible measure. Other lung volumes and flows exhibit greater variability, impacting assessments like bronchial hyper-reactivity.

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    Area of Science:

    • Pediatric Pulmonology
    • Respiratory Physiology

    Background:

    • Pulmonary function testing (PFT) is crucial for diagnosing and monitoring pediatric respiratory conditions.
    • Understanding intrasubject variability in PFT is essential for accurate interpretation of results in children.

    Purpose of the Study:

    • To assess the intrasubject variability of various pulmonary function tests in healthy children.
    • To determine if time of day or re-test interval influences test variability.

    Main Methods:

    • Twenty healthy children (10-16 years) underwent repeat PFTs up to 11 times over two months.
    • Tests included spirometry, flow-volume curves, lung volumes via body plethysmography, and single-breath nitrogen washout.
    • Standard deviation and coefficient of variation were used to analyze variability.

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    Main Results:

    • Vital capacity (VC) from spirometry demonstrated the least variability.
    • Lung volumes (functional residual capacity, residual volume, total lung capacity) were reproducible but more variable than VC.
    • Flow rates at 25% vital capacity were significantly less variable than other flow measurements.

    Conclusions:

    • VC is the most reliable PFT measurement for intrasubject reproducibility in children.
    • Variability of other PFT parameters should be considered when assessing respiratory conditions, including bronchial hyper-reactivity.
    • Time of day and re-test interval up to two months did not significantly impact variability.