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Statistical moments in pharmacokinetics

K Yamaoka, T Nakagawa, T Uno

    Journal of Pharmacokinetics and Biopharmaceutics
    |December 1, 1978
    PubMed
    Summary
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    Statistical moments quantify drug concentration and excretion over time. These pharmacokinetic parameters, including mean residence time, reveal insights into drug disposition and bioavailability, aiding deconvolution analysis.

    Area of Science:

    • Pharmacokinetics
    • Drug Metabolism and Disposition

    Background:

    • Statistical moments characterize drug concentration-time profiles.
    • Key moments include area, mean residence time, and variance of residence time.
    • These parameters describe drug disposition, encompassing absorption, distribution, metabolism, and excretion (ADME).

    Purpose of the Study:

    • To describe the relationship between statistical moments and pharmacokinetic profiles.
    • To demonstrate the utility of statistical moments in bioavailability assessment.
    • To highlight the application of moments in deconvolution operations.

    Main Methods:

    • Analysis of plasma concentration-time curves.
    • Analysis of urinary excretion rate-time curves.
    • Application of deconvolution techniques.

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    Main Results:

    • Statistical moments effectively describe drug disposition characteristics.
    • Moments correlate with the extent and rate of bioavailability.
    • Demonstrated successful application of moments for deconvolution.

    Conclusions:

    • Statistical moments are valuable pharmacokinetic parameters.
    • They provide a comprehensive understanding of drug disposition.
    • Moments offer a robust method for bioavailability assessment and deconvolution.