[Activity and stability of liver mitochondrial membrane polyenzyme systems in chronic allergic ulcerative colitis]

Activity of NADH-, succinate- and cytochrome c oxidase systems of respiratory chain from rat liver mitochondrial membranes was studied in animals with various type of liver impairment under conditions of chronic allergic ulcerous colitis. Activity of the polyenzymatic systems did not exhibit marked differences as compared with the controls in fatty and chronic dystrophy but the activity was considerably increased if chronic dystrophy progressed and hepatitis developed. In chronic allergic ulcerous colitis resistance of the polyenzymatic oxidase systems to heat treatment was decreased in liver mitochondrial membranes. Under conditions of the pathology proteins and phospholipids from mitochondrial membranes were especially sensitive to the effect of trypsin and phospholipase; the rate of reactions correlated well with the severity of the liver impairment. Development of latent impairments in liver mitochondrial membranes was shown to depend on the severity of the pathological process.