Related Experiment Video
Updated: May 2, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
16.7K
Giant pseudopolyps in Crohn's colitis. A nonoperative approach
The American Journal of Gastroenterology
|September 1, 1981
Summary
Multilobulated masses in Crohn's disease may mimic cancer but are often pseudopolypoid inflammatory tissue. Non-surgical management is appropriate when biopsies confirm this benign finding, avoiding unnecessary surgery.
Area of Science:
- Gastroenterology
- Colorectal Surgery
- Inflammatory Bowel Disease
Background:
- Crohn's disease can present with colonic intraluminal masses.
- These masses can be mistaken for neoplasms, leading to diagnostic challenges.
Purpose of the Study:
- To evaluate the nature of colonic intraluminal masses in patients with Crohn's disease.
- To determine the appropriate management strategy for these masses.
Main Methods:
- Retrospective review of six patients with Crohn's disease and colonic masses.
- Diagnostic methods included barium enema, colonoscopy with biopsies, and cytology.
- Surgical intervention and non-surgical follow-up were assessed.
Main Results:
- All six patients had pseudopolypoid inflammatory tissue, not malignancy.
- One patient experienced a fatal postoperative complication (sepsis and abscess).
- Three patients managed non-surgically showed no changes over 4.5 years of follow-up.
Conclusions:
- Intraluminal colonic masses in Crohn's disease can represent pseudopolypoid inflammatory tissue.
- Endoscopic surveillance with biopsies and cytology can confirm benign findings.
- Surgery may not be mandatory, potentially avoiding risks associated with operative procedures.
More Related Videos
Related Concept Videos
01:29Drugs for Treatment of Ulcerative Colitis in IBD
705
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
705
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
692
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
692
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
01:21Inflammatory Bowel Disease V: Surgical Management
917
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
917
01:26Inflammatory Bowel Disease I: Introduction
42
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
42