Eruptive keratoacanthoma with an internal malignant neoplasm

Area of Science:

• Dermatology
• Oncology
• Pathology

Background:

• Keratoacanthoma is a common skin tumor, but eruptive keratoacanthoma is a rare variant.
• This condition is characterized by the sudden onset of numerous keratoacanthomas.
• Association with internal malignancies is infrequently reported.

Observation:

• A 65-year-old woman presented with hundreds of tumors on sun-exposed skin and oral lesions.
• Biopsy confirmed the diagnosis of keratoacanthoma for all lesions.
• An asymptomatic ovarian carcinoma was incidentally discovered during further examination.

Findings:

• This case represents the second documented instance of eruptive keratoacanthoma co-occurring with an internal malignant neoplasm.
• The findings suggest a potential link between eruptive keratoacanthoma and internal cancers.

Implications:

• Widespread keratoacanthoma should prompt a thorough investigation for underlying internal malignancies.
• Early detection of associated cancers can improve patient outcomes.
• Further research is warranted to elucidate the pathobiology of eruptive keratoacanthoma and its association with cancer.