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[Experimental autoimmune glomerulonephritis replicated in several generations of immunized animals]
Experimental autoimmune glomerulonephritis was reproduced in 10 generations of animals by parenteral inoculation on two occasions of 0.3 ml of a mixture (1 :1) of AF stimulator and 20% renal cortical layer homogenate. The animals were immunized with minimal doses which routinely did not cause renal pathology, however, in sequential regular immunization from generation to generation the renal pathology increased. The forth-fifth generation exhibited clinical signs typical of glomerulonephritis. Morphological examinations of the kidneys revealed mesangial-proliferative and membranous-proliferative glomerulonephritis.
Experimental autoimmune glomerulonephritis was reproduced in 10 generations of animals by parenteral inoculation on two occasions of 0.3 ml of a mixture (1 :1) of AF stimulator and 20% renal cortical layer homogenate. The animals were immunized with minimal doses which routinely did not cause renal pathology, however, in sequential regular immunization from generation to generation the renal pathology increased. The forth-fifth generation exhibited clinical signs typical of glomerulonephritis. Morphological examinations of the kidneys revealed mesangial-proliferative and membranous-proliferative glomerulonephritis.