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Brain stimulation as a cue for event-related potentials in rat cortex: amphetamine effects
The International Journal of Neuroscience
|January 1, 1981
Summary
Frontal cortex slow potential (SP) responses develop with reward anticipation, even without sensory cues. Amphetamine suppresses these SP responses, indicating it doesn't disrupt auditory pathways.
Area of Science:
- Neuroscience
- Behavioral Neuroscience
- Psychopharmacology
Background:
- Slow potential (SP) responses in the frontal cortex are associated with anticipation of rewarding stimuli.
- Previous studies often used peripheral sensory cues to elicit these anticipatory responses.
Purpose of the Study:
- To investigate if frontal cortex SP responses can develop without peripheral sensory cues.
- To examine the effect of d-amphetamine on these cue-independent SP responses.
Main Methods:
- Rats with implanted electrodes recorded bilateral frontal cortex SP responses.
- A single electrical pulse cue was paired with rewarding brain stimulation.
- d-Amphetamine was administered at varying doses (0.125-0.5 mg/kg) to assess its effects.
Main Results:
- Repeated pairing of the pulse cue with reward led to the development of significant negative SP responses.
- These SP responses extinguished quickly upon removal of reward.
- d-Amphetamine dose-dependently suppressed the SP response to the pulse cue.
Conclusions:
- Frontal cortex SP responses anticipating reward can be established without peripheral sensory input.
- Amphetamine's suppression of these responses is not mediated by auditory system disruption.