Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cholecystokinin in hippocampal pathways

R S Greenwood, S E Godar, T A Reaves

    The Journal of Comparative Neurology
    |December 10, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cardiac integrins the ties that bind.

    Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
    Same author

    Increased brain apparent diffusion coefficient in children with neurofibromatosis type 1.

    Radiology·2001
    Same author

    Outcome in children with fetal mild ventriculomegaly: a case series.

    Schizophrenia research·2001
    Same author

    Neutrophil transepithelial migration: regulation at the apical epithelial surface by Fc-mediated events.

    American journal of physiology. Gastrointestinal and liver physiology·2001
    Same author

    Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.

    Neurology·2001
    Same author

    Inhibition of hippocampal kindling by metabotropic glutamate receptor antisense oligonucleotides.

    Molecular and cellular neurosciences·2000

    This study maps cholecystokinin-like (CCK-L) cells and fibers in the rat hippocampus. CCK-L neurons are found in key hippocampal regions, suggesting a role in its circuitry and connections.

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Neuroanatomy

    Background:

    • Cholecystokinin-like (CCK-L) immunoreactivity is present in the central nervous system.
    • The precise distribution and pathways of CCK-L in the rat hippocampus are not fully elucidated.

    Purpose of the Study:

    • To map the distribution of CCK-L immunoreactive cells and fibers within the rat hippocampal formation.
    • To investigate the afferent and efferent connections of CCK-L immunoreactive elements in the hippocampus.

    Main Methods:

    • Immunoperoxidase technique was employed to visualize CCK-L immunoreactivity.
    • Systematic examination of the hippocampal formation, subiculum, presubiculum, and entorhinal cortex.

    Main Results:

    Related Experiment Videos

  • CCK-L immunoreactive perikarya were identified in the dentate hilus, Ammon's horn, subiculum, presubiculum, and entorhinal cortex.
  • CCK-L immunoreactive fibers were observed throughout these regions, including the alveus, fimbria, and lateral septal nucleus.
  • The distribution suggests CCK-L fibers are part of both afferent and efferent hippocampal pathways, with a notable anteriorly directed efferent pathway.

    • Conclusions:

    • CCK-L neurons are widely distributed within the rat hippocampal formation and its connected areas.
    • The observed fiber distribution indicates CCK-L plays a significant role in hippocampal circuitry and information processing.
    • CCK-L immunoreactivity in the fimbria and lateral septal nucleus points to its involvement in efferent hippocampal projections.