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Updated: Aug 8, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Sarcoid heart disease

H A Fleming, S M Bailey

    Journal of the Royal College of Physicians of London
    |October 1, 1981
    PubMed

    Insights

    Myocardial sarcoidosis, a potentially under-diagnosed UK disease, requires high suspicion for unusual heart conditions, especially with rhythm changes or heart failure. Early diagnosis and energetic treatment are crucial due to high sudden death rates.

    Area of Science:

    • Cardiology
    • Immunology
    • Pathology

    Background:

    • Myocardial sarcoidosis is a significant, potentially under-diagnosed condition in the UK.
    • A high index of suspicion is essential for diagnosing myocardial sarcoidosis, particularly in unexplained heart disease cases.

    Observation:

    • Unusual heart disease presentations, serious rhythm changes, and unexplained heart failure warrant consideration of myocardial sarcoidosis.
    • Mitral systolic murmurs are frequent findings.
    • Cardiac symptoms often dominate, even with minimal involvement of other organs.

    Findings:

    • The heart can be massively involved in sarcoidosis, leading to significant cardiac dysfunction.
    • Sudden death is a disturbingly common outcome for affected patients.
    • A high incidence in East Anglia suggests geographical factors warrant further investigation.

    Implications:

    • Prompt diagnosis and aggressive treatment are indicated, though assessing treatment efficacy remains challenging.
    • Further research is needed to better understand and manage this sinister disease.
    • Increased awareness and diagnostic efforts are crucial for improving patient outcomes.

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