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Ethanol consumption: selective breeding in mice

S M Anderson, G E McClearn

    Behavior Genetics
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Selective breeding created distinct high-ethanol acceptance (HEA) and low-ethanol acceptance (LEA) mouse lines. Realized heritability for ethanol acceptance was estimated at 0.21 after 10 generations.

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    Area of Science:

    • Genetics
    • Behavioral Neuroscience
    • Animal Models

    Background:

    • Ethanol acceptance varies significantly within mouse populations.
    • Selective breeding is a powerful tool for studying complex traits like alcohol consumption.

    Purpose of the Study:

    • To develop and characterize mouse lines with divergent ethanol acceptance.
    • To estimate the realized heritability of ethanol acceptance.
    • To examine correlations between different measures of alcohol consumption.

    Main Methods:

    • Mass selection was applied to a foundation stock of HS/Ibg mice over 10 generations to create high-ethanol acceptance (HEA) and low-ethanol acceptance (LEA) lines.
    • Realized heritability was estimated based on the divergence between HEA and LEA lines.
    • Correlations among three different methods for measuring alcohol consumption were assessed in an F2 generation derived from C57BL/Ibg and C3H/Ibg mice.

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    Main Results:

    • After 10 generations, the HEA and LEA lines exhibited distributions with minimal overlap.
    • The estimated realized heritability for ethanol acceptance was 0.21 +/- 0.04.
    • Low to moderate correlations were observed among the three methods used to measure alcohol consumption.

    Conclusions:

    • Selective breeding is effective in creating mouse lines with substantially different levels of ethanol acceptance.
    • Ethanol acceptance in mice is a heritable trait with a moderate genetic component.
    • Different methods for assessing alcohol consumption show varying degrees of correlation, highlighting the complexity of measurement.