Chemical ionization mass spectrometric examination of metabolized toxaphene from milk fat

Gas chromatographic mass spectrometric techniques using methane chemical ionization have been employed to characterize the chemical composition of Toxaphene reference material, as well as the metabolized residue in milk fat resulting from controlled administration to cows. The results indicated that selection of particular ions can be of great value in determining whether or not an observed residue by electron capture should be attributed to a metabolized residue of Toxaphene. Analysis of six commercial milk samples by electron capture gas chromatography and gas chromatography mass spectrometry/chemical ionization/selected ion monitoring has provided semi-quantitative data for comparison of the determinative step.