[Reactive changes in liver stroma following zymosan administration]

Male (CBA x C57BI)F1 mice weighing 18-22 g received zymosan intravenously in a dose of 2 mg. After 2 days numerous mononuclear foci could be seen in the liver. Most cells from the infiltrates were strongly acid phosphatase-positive. The slice surface under the infiltrates gradually increased and 5 days after zymosan injection occupied 25% of the total slice surface. The number of the infiltrates increased almost 5-fold from the 2d to the 5th day of experiment. Liver infiltration was accompanied by pronounced monocytosis. Activation of any type of liver sinusoidal cells was revealed by electron microscopy. The evidence obtained shows that activated Kupffer macrophages may give rise to the formation of liver mononuclear infiltrates.