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Updated: Jul 29, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
Published on: July 22, 2011
Study of some immunity parameters in patients receiving low-caloric diets
V I Shcherbakov1, I M Pozdnyakov
1Research Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. sck@cyber.ma.nsc.ru
Abstract:
The immunoregulatory effect of low-caloric diets on various components of the immune system was demonstrated. Serum content of TNF-alpha increased after the diet. Seasonal fluctuations in this parameter were observed in patients receiving these diets. A relationship between the increase in TNF-alpha level and body weight loss during low-caloric diet was detected. Presumably, transition to endogenous nutrition triggers not only catabolic hormones, but also cytokines with catabolic effects.

