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Related Experiment Videos

Locomotor control in macaque monkeys

E Eidelberg, J G Walden, L H Nguyen

    Brain : a Journal of Neurology
    |December 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Primates do not exhibit spinal stepping after cord transection. However, brainstem stimulation can elicit controlled locomotion, suggesting supraspinal control is crucial for primate walking.

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    Area of Science:

    • Neuroscience
    • Primate locomotion
    • Spinal cord research

    Background:

    • Understanding the neural basis of locomotion is crucial for neuroscience.
    • Spinal pattern generators are known to control rhythmic movements in some species.
    • The role of supraspinal control in primate locomotion remains incompletely understood.

    Purpose of the Study:

    • To investigate the existence and function of spinal pattern generators in primates.
    • To determine the role of brainstem locomotor regions in primate locomotion.
    • To compare primate locomotor control mechanisms with those of other mammals, like cats.

    Main Methods:

    • Experiments were conducted on adult macaque monkeys (M. fascicularis).
    • Spinal cord transection was performed to assess 'spinal stepping'.

    Related Experiment Videos

  • Electrical stimulation of specific brainstem regions (posterior subthalamic and midbrain tegmentum) was used to elicit locomotion.

    • Main Results:

    • 'Spinal stepping' could not be induced in monkeys after spinal cord transection.
    • Preservation of specific white matter pathways in the spinal cord was sufficient for stepping and walking.
    • Electrical stimulation of the posterior subthalamic region or midbrain tegmentum successfully elicited 'controlled locomotion' in thalamic monkeys.

    Conclusions:

    • Primates possess supraspinal locomotor control structures homologous to those in cats.
    • Unlike cats, primate spinal step generators appear to heavily rely on supraspinal inputs for function.
    • Locomotion in primates is significantly dependent on descending control from brainstem locomotor regions.