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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
[Acute myocardial infarction of the right ventricle: hemodynamic and electrocardiographic correlation (author's
Insights
Diagnosing acute myocardial infarction of the right ventricle (AMI-RV) using electrocardiograms (ECG) has limited value. Hemodynamic monitoring is the preferred diagnostic method for AMI-RV, offering better accuracy than ECG in identifying the condition.
Area of Science:
- Cardiology
- Diagnostic Imaging
Context:
- Acute myocardial infarction of the right ventricle (AMI-RV) presents diagnostic challenges.
- Prospective study involving 66 patients in a coronary unit.
Purpose:
- To evaluate the diagnostic utility of electrocardiography (ECG) in AMI-RV.
- To compare ECG findings with hemodynamic monitoring in diagnosing AMI-RV.
Summary:
- Standard and special ECG modes showed limited sensitivity (54%) and specificity (23%) for AMI-RV, with no improvement for anterior infarctions.
- Hemodynamic monitoring demonstrated a better correlation with the site of necrosis than ECG ST segment changes.
- Right ventricular dysfunction was identified in 17% of patients, left ventricular in 9%, and biventricular in 20%.
Impact:
- Hemodynamic monitoring is the preferred diagnostic procedure for AMI-RV.
- ECG is of limited value in diagnosing AMI-RV, particularly for anterior locations.
- Suspect AMI-RV if serial studies show a pulmonary wedge pressure (PVC) increase of more than 9 mm Hg.
Abstract:
The electrocardiogram as a diagnostic aid in acute myocardial infarction of the right ventricle (AMI-RV) was studied prospectively in a group of 66 patients in our coronary unit. Diagnosis was AMI in all cases, divided into 29 (44%) with posterior-descending and 35 (53%) with anterior location. Electrocardiography was practiced with standard and special modes: CRnR, CR and VR. Thirty-nine patients were hemodynamically monitored. In 13 patients with posterior-descending location (19.6%) the hemodynamic pattern disclosed AMI. Right ventricular dysfunction was found in 17%, left ventricular dysfunction in 9% and biventricular dysfunction in 20%. In 30 patients (45.5%) ST increased to greater than 1 mm CR3R-CR6R of which 77% were false positive and 46% false negative. No improvement in these proportions was observed with the use of special mode, special in infarctions with anterior location. The correlation between hemodynamics-site of necrosis was better than that between hemodynamics-increase in ST in CRnR. The authors draw the conclusion that special modes as an aid to diagnosis are of limited value, sensitivity is 54% and specificity is 23%, which rises to 50% in posterior-descending infarctions. At present hemodynamics are the choice diagnostic procedure for AMI-RV which must be suspected if serial studies disclose PVC of more than 9 mm Hg.
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