[Clinico-rheographical correlations in patients with cerebrovascular disorders treated with intravenous cinnarizine]

The aim of this study was to investigate the effects of parenteral administration of Cinnarazin on cerebral haemodynamics by means of rheoencephalography in patients with cerebrovascular diseases. The studied group included 32 patients aged from 39 to 78 years. Cinnarazin was given in doses of 25 to 50 mg (3-6) intravenously daily for 10 days. Rheoencephalographic investigations were carried out repeatedly (before intravenous Cinnarazin and during 30-60 minutes after injection of the preparation at intervals of 5-10 minutes). The investigations showed that: 1) intravenous Cinnarazin produced in patients with cerebrovascular diseases good effects, particularly in cases of transient circulatory disturbances in the brain, particularly in cases of atrial rhythm disorders, 2) particularly evident rheoencephalographic changes developed after from 10 to 20 minutes after Cinnarazin administration intravenously and were recorded during 2 hours, according to clinical data the effect of the treatment persisted during three months after completion of treatment.