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Abstract:
Six principal strains of rats have been selected to develop spontaneous or induced hypertension, the SHR (Okamoto) strain alone being widely used by experimenters. This is the case in France and it is to be desired that investigations are extended at two levels: introduction of new substrains; improvement and comparative genetic study of available strains. The Centre de Sélection et d'Elevage d'Animaux de Laboratoire is already engaged in that way, making every effort to promote the utilization of the newly obtained SHR SP subline as well as that of the SHR-fa subline which is in the process of being established.