Related Experiment Videos
[A new plasma exchange technique : coagulation studies (author's transl)]
Nouvelle Revue Francaise D'Hematologie
|January 1, 1981
Summary
Plasma exchange using Plasmaflo filtration moderately reduced platelet counts and significantly decreased coagulation factors. Factor VIII levels normalized rapidly post-procedure, with no major bleeding complications observed.
Area of Science:
- Hematology
- Neurology
- Biomaterials
Context:
- Continuous plasma exchange (PE) is a therapeutic apheresis technique.
- Neurologic disorders are increasingly managed with PE.
- Evaluating new filtration materials is crucial for optimizing PE procedures.
Purpose:
- To assess coagulation factor levels and clinical outcomes during and after plasma exchange using the "Plasmaflo" filtration system.
- To investigate the impact of massive heparinization during PE on coagulation parameters.
- To evaluate the recovery kinetics of specific coagulation factors post-procedure.
Summary:
- Fifteen patients with neurologic disorders underwent 60 continuous plasma exchanges using "Plasmaflo" filtration, with isovolumetric replacement by albumin and Plasmion.
- Coagulation studies revealed a moderate platelet reduction (19%) and a significant, rapid decrease (70%) in coagulation factors during PE.
- Factor VIII (VIII:C and VIII R:Ag) showed rapid normalization within 3 hours post-exchange, sometimes increasing during the procedure.
- While no hemorrhagic diathesis occurred despite heparin and reduced factors, one patient developed deep vein thrombosis.
Impact:
- The "Plasmaflo" filter demonstrates efficacy in plasma exchange for neurologic disorders.
- Understanding coagulation factor dynamics, especially Factor VIII, is vital for managing PE patients.
- The study highlights the need for vigilance regarding thrombotic events despite anticoagulation and reduced procoagulant factors.