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Platelet-derived growth factor (PDGF) enhances the growth of Moloney sarcoma virus-induced tumors in mice
Abstract:
The intramuscular (i.m.) administration of bovine or human platelet derived growth factor (PDGF) had a marked potentiating effect on the growth of Moloney sarcoma virus (MSV)-induced tumors in Balb/c mice. PDGF had the tumor-promoting-activity when administered i.m. on the side of inoculation of MSV two days after the virus, and subsequently every second day for 2-3 weeks. The extent of MSV-induced tumor promoting activity of PDGF was age and sex-related. In view of the recently described antagonism in action between growth factors and interferons it is suggested that both families of hormones play an important role in controlling the neoplastic proliferation.
Insights
Platelet-derived growth factor (PDGF) enhances Moloney sarcoma virus (MSV)-induced tumor growth in mice. This tumor-promoting activity is influenced by animal age and sex, suggesting a role for growth factors in cancer progression.
Area of Science:
- Oncology
- Virology
- Molecular Biology
Background:
- Platelet-derived growth factor (PDGF) is a potent mitogen involved in cell growth and tissue repair.
- Moloney sarcoma virus (MSV) is a retrovirus known to induce tumors in susceptible animal models.
- Interferons are known to have antiviral and antiproliferative effects.
Purpose of the Study:
- To investigate the effect of PDGF administration on the growth of MSV-induced tumors in Balb/c mice.
- To determine if PDGF exhibits tumor-promoting activity in this model.
- To explore the influence of age and sex on PDGF's tumor-promoting effects.
Main Methods:
- Intramuscular (i.m.) administration of bovine or human PDGF.
- Administration was performed on the side of MSV inoculation, starting two days post-infection and continuing every second day for 2-3 weeks.
- Tumor growth was monitored in Balb/c mice.
Main Results:
- Intramuscular PDGF administration significantly potentiated the growth of MSV-induced tumors.
- PDGF demonstrated tumor-promoting activity when administered post-MSV inoculation.
- The extent of PDGF's tumor-promoting activity was found to be age- and sex-dependent.
Conclusions:
- PDGF plays a significant role in promoting the growth of MSV-induced tumors.
- The findings suggest a complex interplay between growth factors like PDGF and interferons in controlling neoplastic proliferation.
- Age and sex are critical factors modulating the response to PDGF in tumor development.