Determination of glomerular filtration rate by 111In-DTPA

To evaluate the use of 111indium-diethylenetriamine pentaacetic acid (111In-DTPA) for determination of the glomerular filtration rate (GFR), the results of 60 standard 111In-DTPA clearances were compared with 24-h urine endogenic creatinine clearances obtained on 3 successive days (r = 0.97, P less than 0.001) and with endogenic creatinine clearances obtained during 111In-DTPA determinations (r = 0.93, P less than 0.0001). It is concluded that 111In-DTPA is a useful marker for GFR.