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Radiolucent gallstone dissolution with bedtime UDCA administration

D Conte, A Bozzani, L Sironi

    Digestion
    |January 1, 1981
    PubMed
    Summary
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    Ursodeoxycholic acid (UDCA) effectively dissolves radiolucent gallstones, with an 85% dissolution rate in patients. Smaller gallstones (<4 mm) achieved 100% dissolution, and no side effects were reported.

    Area of Science:

    • Gastroenterology
    • Hepatology
    • Pharmacology

    Background:

    • Gallstones are a common condition affecting a significant portion of the population.
    • Radiolucent gallstones, often composed of cholesterol, pose a treatment challenge.
    • Ursodeoxycholic acid (UDCA) is a bile acid used for gallstone dissolution.

    Purpose of the Study:

    • To evaluate the efficacy and safety of a 600 mg single bedtime dose of ursodeoxycholic acid (UDCA) for dissolving radiolucent gallstones.
    • To compare the dissolution rates between a single bedtime dose and a multi-dose regimen of UDCA.

    Main Methods:

    • A study involving 26 patients with radiolucent gallstones (diameter ≤10 mm).
    • Treatment with a single daily dose of 600 mg ursodeoxycholic acid (UDCA) at bedtime for 6 months.

    Related Experiment Videos

  • Comparison with a historical or parallel series of patients receiving UDCA at mealtimes (10-12 mg/kg/day).

    • Main Results:

    • An overall partial and complete dissolution rate of 85% was achieved with the bedtime UDCA regimen.
    • 100% dissolution rate was observed for gallstones with a diameter less than 4 mm.
    • No adverse side effects were reported during the treatment period.

    Conclusions:

    • A single daily 600 mg dose of ursodeoxycholic acid (UDCA) administered at bedtime is an effective and safe treatment for radiolucent gallstones.
    • This dosage regimen is particularly effective for smaller gallstones (<4 mm).
    • The efficacy of the bedtime UDCA regimen is comparable to multi-dose regimens, suggesting a convenient and effective therapeutic option.