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Haemosiderin deposits in the human cornea
Journal of Submicroscopic Cytology
|July 1, 1981
Summary
Iron deposits, called siderosomes, were found in corneal cells after eye trauma and bleeding. Analysis confirmed these deposits contain iron, phosphorous, and sulphur, explaining the siderotic cornea.
Area of Science:
- Ophthalmology
- Cell Biology
- Materials Science
Background:
- Siderotic cornea is a rare condition characterized by iron deposition.
- Post-traumatic hyphaemia can lead to intraocular complications.
Purpose of the Study:
- To investigate the cellular and elemental composition of a siderotic cornea following trauma.
Main Methods:
- Corneal tissue from a post-traumatic hyphaemia case was examined.
- Siderosomes were identified in corneal fibroblasts, epithelial, and endothelial cells.
- Electron-probe x-ray analysis was performed on siderosomes.
Main Results:
- Large numbers of siderosomes were observed in corneal fibroblasts.
- Siderosomes were also present in corneal epithelial and endothelial cells.
- Analysis revealed the presence of iron, phosphorous, and sulphur within the siderosomes.
Conclusions:
- The study identified siderosomes as the source of iron deposition in the cornea post-trauma.
- The elemental composition of siderosomes was confirmed to be iron, phosphorous, and sulphur.
- These findings contribute to understanding the pathophysiology of siderotic cornea.