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Related Experiment Videos

Chronic aflatoxicosis in cattle

J Vaid, R K Dawra, O P Sharma

    Veterinary and Human Toxicology
    |December 1, 1981
    PubMed
    Summary

    Chronic aflatoxicosis in cattle, caused by contaminated feed, leads to liver damage. Pathological and hematological studies revealed significant liver injury in affected milk cattle.

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    Area of Science:

    • Veterinary medicine
    • Toxicology
    • Animal pathology

    Background:

    • Aflatoxicosis is a significant health concern in livestock.
    • Contaminated feed, particularly groundnut cake, is a common source of aflatoxins.
    • Chronic exposure can lead to severe health issues in cattle.

    Purpose of the Study:

    • To investigate the pathological, hematological, and enzymatic changes in cattle with chronic aflatoxicosis.
    • To assess the effects of prolonged aflatoxin B1, B2, G1, and G2 exposure.
    • To correlate clinical and necropsy findings with liver function tests.

    Main Methods:

    • Clinical examination and necropsy of affected milk cattle.
    • Histopathological examination of liver tissues.
    • Hematological analysis and plasma enzyme level determination.
    • Analysis of feed for aflatoxin B1, B2, G1, and G2 content.

    Main Results:

    • Proliferation of connective tissue along portal triads in the liver was observed.
    • Small groups of hepatocytes remained intact despite significant pathological changes.
    • Liver function tests indicated liver damage in 75% of the affected animals studied.
    • Aflatoxin B1 levels in groundnut cake were found to be 110 ug/kg.

    Conclusions:

    • Chronic aflatoxicosis significantly impacts liver health in milk cattle.
    • The observed pathological changes are indicative of prolonged exposure to aflatoxins.
    • Liver function tests are valuable in diagnosing aflatoxicosis in cattle.

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