[Determination of the half-life of liver proteins in very old rats]

The turnover rate of rat liver cytosol proteins was calculated by means of NaH14CO3-pulse labeling and following the decay of this label up to the 10th day after application of the precursor. Maximum incorporation of the precursor into the cytosol proteins has been found to be 40 minutes after its administration. The half-life was calculated in animals 21 and 27 months of age to be 2,8 days, which is by 50% longer in comparison to adult young animals.