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Related Experiment Videos

Reduced physical work capacity at high altitude--a role for left ventricular dysfunction

S Saksena, S C Manchanda, S B Roy

    International Journal of Cardiology
    |January 1, 1981
    PubMed
    Summary

    Lowlanders (LL) experience reduced physical work capacity at high altitudes due to impaired cardiac performance. Furosemide administration did not improve this capacity in lowlanders at high altitude.

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    Area of Science:

    • Physiology
    • Altitude Medicine
    • Cardiovascular Research

    Background:

    • Sea level residents (lowlanders) exhibit reduced physical work capacity at high altitudes compared to high altitude natives (highlanders).
    • Understanding the underlying physiological mechanisms is crucial for addressing altitude-related limitations.

    Purpose of the Study:

    • To investigate the cardiac performance differences between lowlanders and highlanders.
    • To determine the impact of high altitude exposure on lowlanders' cardiac function and physical work capacity.
    • To assess the effect of furosemide on cardiac performance in lowlanders at high altitude.

    Main Methods:

    • Systolic time intervals were used to assess cardiac performance in healthy male lowlanders and highlanders during rest, submaximal, and maximal exercise.

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  • Lowlanders were studied at sea level and after 10 days at 3658 m; highlanders were studied at high altitude.
  • The effect of intravenous furosemide was evaluated in lowlanders at high altitude.

    • Main Results:

    • Lowlanders showed a 26% reduction in maximal oxygen uptake (VO2max) at high altitude compared to sea level.
    • The pre-ejection period/left ventricular ejection time ratio, an indicator of cardiac performance, significantly increased in lowlanders at high altitude during exercise.
    • Furosemide administration increased heart rate but did not alter VO2max or cardiac performance in lowlanders at high altitude.

    Conclusions:

    • Reduced physical work capacity in lowlanders at high altitude may be linked to depressed cardiac performance.
    • Intravenous furosemide does not appear to improve cardiac performance or physical work capacity in lowlanders acclimatizing to high altitude.