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Acute phase reactant proteins in prostatic cancer

A M Ward, E H Cooper, A L Houghton

British Journal of Urology

|October 1, 1977

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This study introduces an acute phase reactant protein profile for prostate cancer patients. This profile aids in diagnostic staging and monitoring oestrogen therapy effectiveness.

Area of Science:

Biochemistry
Oncology
Clinical Chemistry

Background:

Prostate cancer diagnosis and staging require accurate assessment.
Monitoring therapeutic response is crucial for patient management.

Purpose of the Study:

To investigate the utility of acute phase reactant proteins in prostate cancer.
To establish a protein profile for diagnostic staging and therapy control.

Main Methods:

Analysis of serum acute phase reactant proteins.
Application of linear discriminant function analysis.
Inclusion of serum acid phosphatase, prealbumin, alpha1 antitrypsin, alpha1 acid glycoprotein, and haptoglobin.

Main Results:

A specific protein profile demonstrated 88.6% accuracy in identifying metastatic prostate cancer.

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The profile may assist in evaluating the physiological effects of oestrogen treatment.

Conclusions:

Acute phase reactant protein profiling is a valuable tool for prostate cancer management.
This method can aid in assessing treatment adherence and efficacy.