Kinetics of indoprofen in patients with renal insufficiency (a preliminary report)

Plasma and urinary indoprofen concentrations were determined by liquid chromatography in healthy subjects and two patients with reduced glomerular filtration rate (GFR) of about 25 ml/min. The plasma half-life of the drug was prolonged in renal insufficiency. Until further studies have been performed indoprofen should be used with care in patients with renal impairment. Tentatively, the size of the dose or interval should be adjusted in proportion to the estimated preserved GFR.