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Morphological observations of peripheral nerves by the scanning electron microscope
Folia Psychiatrica Et Neurologica Japonica
|January 1, 1981
Summary
Scanning electron microscopy revealed hypertrophied Schwann cells in changed peripheral nerves. These cells formed a pseudosyntitium, suggesting a reversal of normal nerve development.
Area of Science:
- Neuroscience
- Cell Biology
Background:
- Schwann cells are crucial for peripheral nerve development and maintenance.
- Understanding cellular changes in nerve injury is vital for regenerative medicine.
Purpose of the Study:
- To investigate the ultrastructural changes in peripheral nerve fibers using scanning electron microscopy.
- To characterize the morphology of Schwann cells in altered nerve conditions.
Main Methods:
- Scanning electron microscopy (SEM) was employed to visualize normal and altered peripheral nerve tissues.
- Comparative analysis of Schwann cell morphology and arrangement in both nerve types.
Main Results:
- Altered nerve fibers exhibited significant Schwann cell hypertrophy.
- Numerous Schwann cell processes formed a syncytium-like structure, ensheathing the nerve fibers.
- This observed structure differed markedly from normal peripheral nerve morphology.
Conclusions:
- The hypertrophied Schwann cells and their unique arrangement suggest a potential reversal of developmental processes in peripheral nerve alteration.
- These findings provide new ultrastructural insights into nerve pathology and Schwann cell behavior.