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A mathematical model of drug absorption
Journal of Clinical and Hospital Pharmacy
|June 1, 1981
Summary
This study presents a model for intestinal drug absorption, considering physical factors like mass transfer resistance. The model helps predict how drug properties affect bioavailability, aligning with physiological data.
Area of Science:
- Pharmacokinetics
- Biopharmaceutics
- Physical Chemistry
Background:
- Intestinal drug absorption is crucial for bioavailability.
- Understanding the physical factors influencing absorption is complex.
- Existing models may not fully capture all relevant parameters.
Purpose of the Study:
- To develop a comprehensive model for intestinal drug absorption.
- To incorporate physical factors, including mass transfer resistance.
- To provide a framework for analyzing drug bioavailability.
Main Methods:
- Formulation of a mathematical model for absorption rate.
- Inclusion of mass transfer resistance in aqueous and lipid phases.
- Comparison of model-derived constants with physiological and physical data.
Main Results:
- The model quantifies absorption rate based on physical parameters.
- It considers resistance in both the surrounding aqueous phase and the membrane lipid phase.
- Experimental constants align with estimations from physiological and physical data.
Conclusions:
- The presented model offers a robust framework for studying intestinal drug absorption.
- Physical parameters significantly influence drug bioavailability.
- The model's validity is supported by the agreement between experimental and estimated constants.