Combined vasodilator therapy in the treatment of chronic heart failure

Treatment of resistant congestive cardiac faiure by vasodilators is now well accepted. Twelve such patients were started on Isosorbide Dinitrate and Hydralazine therapy and monitored for 24 hours. Oral treatment was then continued indefinitely. This group responded well to combined therapy and four had their regimes altered in the light of haemodynamic observations. It was then concluded that this type of treatment can be tailored to the individual patient to produce the best effects on preload and afterload.