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Related Experiment Videos

Calcification in the human lens

P Fagerholm, B Philipson, D Carlström

    Current Eye Research
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Calcification in a child's cataract involves a hydroxyapatite shell forming in the lens cortex. This study suggests a cell-induced mechanism for this rare ocular calcification in chronic uveitis.

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    Area of Science:

    • Ophthalmology
    • Biomineralization
    • Cell Biology

    Background:

    • Cataracts are a leading cause of vision loss, often associated with aging.
    • Ocular calcification, particularly in pediatric cataracts, is uncommon and poorly understood.
    • Chronic uveitis can lead to various intraocular complications, including cataract formation.

    Observation:

    • A 12-year-old boy with chronic uveitis presented with a calcified cataractous lens.
    • Microradiography, X-ray crystallography, and transmission electron microscopy were employed for analysis.
    • A distinct 0.2 mm thick calcified shell was identified in the subcapsular cortex.

    Findings:

    • The mineral component was identified as well-crystallized hydroxyapatite with randomly oriented crystals.

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  • The underlying lens cortex contained a fibrous matrix with collagen fibers and cellular elements.
  • Epithelioid cells, fibroblast-like cells, and membrane-enclosed vesicles were observed within the matrix.

    • Implications:

    • The findings suggest a cell-induced mechanism for the observed ocular calcification.
    • Understanding this process may offer new insights into managing pediatric cataracts associated with inflammation.
    • Further research into cellular pathways of biomineralization in the eye is warranted.