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Cirrhosis of liver
Bangladesh Medical Research Council Bulletin
|December 1, 1981
Summary
This study analyzes 293 cirrhosis cases in Dacca, finding viral hepatitis a likely cause in non-alcoholic patients. Cryptogenic cirrhosis was most common, highlighting distinct etiological factors in the region.
Area of Science:
- Hepatology
- Internal Medicine
- Clinical Epidemiology
Background:
- Cirrhosis is a significant health concern globally.
- Understanding the etiological factors and clinical presentation of cirrhosis is crucial for effective management.
- Previous studies have focused on alcoholic cirrhosis, necessitating research into non-alcoholic causes.
Purpose of the Study:
- To analyze the clinical characteristics of cirrhosis patients in Dacca.
- To identify the primary etiological factors contributing to cirrhosis in this population.
- To compare clinical features with international findings, particularly in non-alcoholic cases.
Main Methods:
- Retrospective clinical analysis of 293 cirrhosis cases.
- Data collected from two moderate-sized hospitals in Dacca.
- Inclusion criteria: patients with overt cirrhosis manifestations.
Main Results:
- The most affected age group was over 40, with a male predominance (51.2%).
- Viral hepatitis (21.5%) was a significant past history, unlike alcoholism (5.5%).
- Common symptoms included weakness (84.3%), weight loss (72%), and ascites (45%); cryptogenic cirrhosis was most frequent (43.7%).
Conclusions:
- Viral hepatitis is presumed the leading etiological factor in this cohort, especially in the absence of alcoholism.
- Clinical features align with non-alcoholic cirrhosis reported elsewhere.
- Cryptogenic cirrhosis represents a substantial proportion, underscoring the need for further etiological investigation.