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Hepatocellular dysfunction in early sepsis despite increased hepatic blood flow
Advances in Shock Research
|January 1, 1981
Summary
Hepatocellular dysfunction occurs early in sepsis, even with increased blood flow. Liver enzyme levels and indocyanine green clearance indicate impaired liver function in early and late sepsis stages.
Area of Science:
- Hepatology
- Sepsis Pathophysiology
- Liver Function Tests
Background:
- Hepatic failure is a known complication of late-stage sepsis.
- Early sepsis is characterized by hyperdynamic circulation, hyperglycemia, and hyperinsulinemia.
- The impact of early sepsis on hepatocellular function remains unclear.
Purpose of the Study:
- To investigate hepatocellular function during early and late sepsis.
- To assess alterations in indocyanine green (ICG) clearance and hepatic enzyme levels in sepsis models.
Main Methods:
- Sepsis was induced in rats using cecal ligation and puncture (CLP).
- Indocyanine green (ICG) clearance and serum levels of hepatic enzymes (SGOT, SGPT) were measured at 10 hours (early sepsis) and 16 hours (late sepsis) post-CLP.
- Total hepatic blood flow (THBF) was measured using hydrogen polarography.
Main Results:
- In early sepsis (10 hours post-CLP), THBF increased, but ICG half-life (T/2) and serum SGOT/SGPT levels significantly increased, indicating impaired liver function.
- In late sepsis (16 hours post-CLP), THBF decreased, with further increases in ICG T/2 and liver enzyme levels.
- Hepatocellular dysfunction was evident even in the early phase of sepsis.
Conclusions:
- Hepatocellular dysfunction occurs during early sepsis, despite increased hepatic blood flow.
- Progressive liver dysfunction accompanies the decrease in hepatic blood flow in late sepsis.
- These findings highlight the early onset of liver impairment in sepsis.