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Sarcoidosis and protein losing enteropathy
Gastroenterology
|January 1, 1980
Summary
Sarcoidosis can cause protein losing enteropathy, leading to immune deficiencies. Prednisone treatment effectively resolved these issues in a reported case.
Area of Science:
- Gastroenterology
- Immunology
- Pulmonology
Background:
- Sarcoidosis is a multisystem inflammatory disease.
- Protein losing enteropathy (PLE) can cause hypoproteinemia and immune dysfunction.
- The association between sarcoidosis and PLE is rare.
Observation:
- A patient presented with symptoms suggestive of PLE, including edema and hypoproteinemia.
- Diagnosis revealed intrathoracic sarcoidosis and confirmed enteric protein loss via 51CrCl3 test.
- Lymphography and small bowel biopsy showed granulomatous involvement and intestinal villi abnormalities.
Findings:
- The patient exhibited hypoproteinemia, decreased immunoglobulins, and T-cell lymphopenia.
- Intrathoracic sarcoidosis with retroperitoneal lymph gland involvement was identified.
- Prednisone treatment for 6 months normalized all pathological parameters.
Implications:
- Abdominal lymph node involvement in sarcoidosis may contribute to PLE.
- PLE in sarcoidosis can exacerbate or cause immune derangements.
- This case highlights the importance of investigating PLE in sarcoidosis patients with abdominal lymphadenopathy.
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